YU Jianhua;YOU Li;WANG Qiang;ZHAO Peng;QIAN Haidong;Sports Department, Nanjing University of Aeronautics and Astronautics;Department of Rehabilitation Medicine, The Affiliated Brain Hospital of Nanjing Medical University;Department of Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School;Zhangjiagang Sports School;To clarify the dynamic changes and clinical significance of heart rate variability in adolescent depression with aerobic exercise therapy, 60 students of mild to moderate depression enrolled in 2022 were divided into the study group(5 cases dropped, 25 cases completed) and the control group(2 cases dropped, 28 cases completed) equally. The patients in the study group received aerobic exercise therapy for 12 weeks, the patients in the control group did not receive any treatment.The clinical efficacy and heart rate variability index between the two groups were compared.The clinical efficacy and cure rate of the study group were significantly higher than those of the control group at the end of the 12th week(P<0.05).The 17-item Hamilton Depression Scale(HAMD-17) score in the two groups was significantly lower than that at baseline(P<0.01).Compared with the control group, the study group showed a more significant decrease in HAMD-17 at the end of the 12th week(P<0.001). The standard deviation of NN intervals(SDNN),standard deviation average of NN intervals(SDANN), and root mean square of successive RR interval differences(RMSSD) in the study group at the end of the 12th week were significantly increased than those before treatment(P<0.001).Compared with the control group, the scores of SDNN, SDANN, and RMSSD in the study group at the end of the 12th week changed more significantly(P<0.001). Negative correlations were found between baseline HAMD-17 score and SDNN, SDANN, and RMSSD(r=-0.343, P=0.012; r=-0.328, P=0.017; r=-0.401, P=0.003; respectively). The results indicate that 12-week aerobic exercise can significantly improve depression symptoms and autonomic nervous system function in adolescent depression patients. The severity of depression is related to impaired autonomic nervous system function, and heart rate variability can become a biological indicator for evaluating the efficacy of aerobic exercise in treating depression.
2024 06 v.52;No.216 [Abstract][OnlineView][Download 328K]